Where are stem
cells used

Where are stem cells used

Umbilical cord blood  was successfully used for the first time in 1988 in France. Since then umbilical cord blood was used over 40 000 times for therapies in hospitals around the world. Samples from Stemlab were released for the first time in 2007.Umbilical cord blood  was successfully used for the first time in 1988 in France. Since then umbilical cord blood was used over 40 000 times for therapies in hospitals around the world. Samples from Stemlab were released for the first time in 2007.

 

Currently stem cells from the cord blood are used in medicine as a standard therapy in 80 diseases, there are also clinical trials that use cord blood for both stem cell transplants and emerging therapies in regenerative medicine. See the list of diseases published and revised by EBMT - European Society for Blood and Marrow Transplantion.

 

List of medical conditions treated with stem cells

Acute leukaemias

  • acute lymphoblastic leukaemia (ALL)
  • acute myeloid leukaemia (AML)
  • acute biphenotipic leukaemia
  • poorly differentiated acute leukaemia

Chronic leukaemias

  • chronic myeloid leukaemia (CML)
  • chronic lymphocytic leukaemia (CLL)
  • juvenile chronic myeloid leukaemia (JCML)
  • juvenile myelomonocytic leukaemia (Naegeleg leukaemia) (JMML)

Myelodisplastic syndrome

  • refractory anaemia (RA)
  • refractory anaemia with ringed sideroblasts (RARS)
  • refractory anaemia with excess blasts (RAEB)
  • refractory anaemia with excess blasts in transformation (RAEB-T)
  • chronic myelomonocytic leukaemia (CMML)

Diseases caused by stem cell defect

  • aplastic anaemia(severe)
  • Fanconi anaemia
  • paroxysmal nocturnal haemoglobinuria

Myeloproliferative syndromes

  • acute myelofibrosis
  • myelofibrosis
  • polycythaemia vera
  • Essentials thromb ocythemia

Hyperplastic disorders of lymphatic system

  • non-Hodgkin lymphoma
  • acute lymphogranuloma
  • prolimphocytic leukaemia

Phagocytic disorders

  • Chediak-Higashi syndrome
  • chronic granulomatous disease (CGD)
  • neutrophil actin dysfunction
  • reticular dysgenesis

Disorders caused by the absence or malfunctioning of enzymes

  • mucopolysaccharidoses  (MPS)
  • Scheie syndrome (MPS-IS)
  • Hunter syndrome(MPS-II)
  • Sanfilippo syndrome (MPS-III)
  • Morquio syndrome (MPS-IV)
  • Maroteaux-Lamy syndrome (MPS-VI)
  • Sly syndrome, beta- glucoronidase deficiency (MPS-VII)
  • adrenoleukodystrophy
  • mucolipidosis II
  • Krabbe disease
  • Gaucher disease
  • Niemann-Pick disease
  • Wolman disease
  • metachromatic leukodystrophy

Histiocytic disorders

  • familial erythrophagocytic  lymphohistiocytosis
  • histiocytosis -X
  • hemophagocytosis

Inherited red blood cell abnormalities

  • beta thalassemia
  • pure red cell aplasia
  • sickle cell anaemia

Inherited immune system disorders

  • telangiectasia
  • Kostmann syndrome
  • leukocyte adhesion deficiency
  • DiGeorge syndrome
  • bare lymphocyte syndrome
  • Omenn syndrome
  • severe combined immunodeficiency (SCID)
  • SCID adenosine deaminase deficiency
  • SCID T and B lymphocytes negative
  • SCID T lymphocytes negative and B lymphocytes positive
  • common variable immunodeficiency
  • Wiskotta Aldrich syndrome
  • X-linked lymphoproliferative disorder

Other inherited conditions

  • Lesch-Nyhan syndrome
  • cartilage-hair hypoplasia
  • Glanzmann’s thrombasthenia
  • osteopetrosis (marble bone disease)

Hereditary thrombotic disorders

  • mega-karyocytosis (inherited thrombocythemia)

Plasma cell disorders

  • multiple myeloma
  • plasmocythic leukaemia
  • Waldenström’s macroglobulinemia

Other forms of cancer

  • breast cancer
  • Ewing’s sarcoma
  • neuroblastoma (sympathicoblastoma)
  • kidney cancer

Use of stem cells brings benefits to patients with neurological disorders such as: autism and cerebral palsy

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